TY - JOUR
T1 - Exploring the therapeutic potential of the mitochondrial transfer-associated enzymatic machinery in brain degeneration
AU - Luque-Campos, Noymar
AU - Riquelme, Ricardo
AU - Molina, Luis
AU - Canedo-Marroquín, Gisela
AU - Vega-Letter, Ana María
AU - Luz-Crawford, Patricia
AU - Bustamante-Barrientos, Felipe A.
N1 - Publisher Copyright:
Copyright © 2023 Luque-Campos, Riquelme, Molina, Canedo-Marroquín, Vega-Letter, Luz-Crawford and Bustamante-Barrientos.
PY - 2023/7/27
Y1 - 2023/7/27
N2 - Mitochondrial dysfunction is a central event in the pathogenesis of several degenerative brain disorders. It entails fission and fusion dynamics disruption, progressive decline in mitochondrial clearance, and uncontrolled oxidative stress. Many therapeutic strategies have been formulated to reverse these alterations, including replacing damaged mitochondria with healthy ones. Spontaneous mitochondrial transfer is a naturally occurring process with different biological functions. It comprises mitochondrial donation from one cell to another, carried out through different pathways, such as the formation and stabilization of tunneling nanotubules and Gap junctions and the release of extracellular vesicles with mitochondrial cargoes. Even though many aspects of regulating these mechanisms still need to be discovered, some key enzymatic regulators have been identified. This review summarizes the current knowledge on mitochondrial dysfunction in different neurodegenerative disorders. Besides, we analyzed the usage of mitochondrial transfer as an endogenous revitalization tool, emphasizing the enzyme regulators that govern this mechanism. Going deeper into this matter would be helpful to take advantage of the therapeutic potential of mitochondrial transfer.
AB - Mitochondrial dysfunction is a central event in the pathogenesis of several degenerative brain disorders. It entails fission and fusion dynamics disruption, progressive decline in mitochondrial clearance, and uncontrolled oxidative stress. Many therapeutic strategies have been formulated to reverse these alterations, including replacing damaged mitochondria with healthy ones. Spontaneous mitochondrial transfer is a naturally occurring process with different biological functions. It comprises mitochondrial donation from one cell to another, carried out through different pathways, such as the formation and stabilization of tunneling nanotubules and Gap junctions and the release of extracellular vesicles with mitochondrial cargoes. Even though many aspects of regulating these mechanisms still need to be discovered, some key enzymatic regulators have been identified. This review summarizes the current knowledge on mitochondrial dysfunction in different neurodegenerative disorders. Besides, we analyzed the usage of mitochondrial transfer as an endogenous revitalization tool, emphasizing the enzyme regulators that govern this mechanism. Going deeper into this matter would be helpful to take advantage of the therapeutic potential of mitochondrial transfer.
KW - cellular therapy
KW - degenerative brain disorders
KW - enzymes
KW - fission and fusion
KW - mitochondrial dysfunction
KW - mitochondrial transfer
KW - mitophagy
KW - oxidative damage
UR - http://www.scopus.com/inward/record.url?scp=85167825952&partnerID=8YFLogxK
U2 - 10.3389/fphys.2023.1217815
DO - 10.3389/fphys.2023.1217815
M3 - Review article
AN - SCOPUS:85167825952
SN - 1664-042X
VL - 14
SP - 1
EP - 14
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 1217815
ER -