Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina

Sonia Kunstmann*, Antonio Vukusich, Luis Michea, Cristian Varela, Irene Allende, Sebastián Bravo, Daniela Gainza, Daniela Sepúlveda, Elisa Marusic, Fernando Figueroa

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Background: Diabetes mellitus is an important risk factor for cardiovascular complications among patients on hemodialysis. However, the incidence of these complications among non diabetic patients on hemodialysis is not well known. Aim: To assess the incidence of cardiovascular complications in non diabetic patients on hemodialysis. Patients and methods: Seventy five non diabetic patients aged 55.6 ± 17 years (48 males), receiving hemodialysis three times a week were evaluated with laboratory tests, echocardiogram and a carotid ultrasound. In 26 patients, interleukin 6, tumor necrosis factor alpha, and intercellular adhesion molecule (ICAM-1) were also measured. Patients were followed during two years. Results: The mean lapse of dialysis therapy was 6.5 ± 5 years. The main cause of renal failure was hypertension. Sixty two percent had systolic hypertension, 86% had concentric left ventricular hypertrophy, 43% had atrial dilatation and 60% had calcifications in the thoracic aorta. Compared with normal controls, patients had higher levels of interleukin 6, tumor necrosis factor alpha and ICAM-1. Carotid media thickness was also higher and increased in the two years of follow up. No correlations were found between ventricular hypertrophy and dialysis lapse, packed red cell volume, calcium phosphorus product, parathormone levels or median arterial pressure. No cardiovascular events were recorded during the follow up period. Conclusions: Non diabetic patients on chronic hemodialysis have a high frequency of ventricular hypertrophy, carotid media thickening, aortic calcifications and an increase in proinflammatory cytokines.

Título traducido de la contribuciónCardiovascular assessment of non diabetic patients on hemodialysis
Idioma originalEspañol
Páginas (desde-hasta)351-360
Número de páginas10
PublicaciónRevista Medica de Chile
Volumen137
N.º3
DOI
EstadoPublicada - mar. 2009
Publicado de forma externa

Palabras clave

  • Chronic
  • Cytokines
  • Heart failure
  • Kidney failure

Huella

Profundice en los temas de investigación de 'Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina'. En conjunto forman una huella única.

Citar esto