Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Ursula Wyneken; Juan Jose Marengo; Sergio Villanueva; Dagoberto Soto; Rodrigo Sandoval; Eckart D. Gundelfinger; Fernando Orrego

doi:10.1046/j.1528-1157.2003.17602.x

Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

Ursula Wyneken^*, Juan Jose Marengo, Sergio Villanueva, Dagoberto Soto, Rodrigo Sandoval, Eckart D. Gundelfinger, Fernando Orrego

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34 Citas (Scopus)

Resumen

Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

Idioma original	Inglés
Páginas (desde-hasta)	243-246
Número de páginas	4
Publicación	Epilepsia
Volumen	44
N.º	2
DOI	https://doi.org/10.1046/j.1528-1157.2003.17602.x
Estado	Publicada - 1 feb. 2003

Palabras clave

NMDA receptor Trk B
Postsynaptic densities

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10.1046/j.1528-1157.2003.17602.x

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title = "Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities",

abstract = "Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.",

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T1 - Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

AU - Wyneken, Ursula

AU - Marengo, Juan Jose

AU - Villanueva, Sergio

AU - Soto, Dagoberto

AU - Sandoval, Rodrigo

AU - Gundelfinger, Eckart D.

AU - Orrego, Fernando

PY - 2003/2/1

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N2 - Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

AB - Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid. Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue. Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs. Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

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KW - Postsynaptic densities

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Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities

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