Efecto de la vacuna antineumocócica conjugada 10-valente en el área sur de Santiago de Chile, 2009-2015

Sylvina Alvarado; Gabriel Cavada; Rodolfo Villena; Jan Wilhelm; Isolda Budnik; Cristian Lara; Ximena Salinas; Nury Azpilcueta; María Teresa Valenzuela

doi:10.26633/RPSP.2018.155

Efecto de la vacuna antineumocócica conjugada 10-valente en el área sur de Santiago de Chile, 2009-2015

Sylvina Alvarado^*, Gabriel Cavada, Rodolfo Villena, Jan Wilhelm, Isolda Budnik, Cristian Lara, Ximena Salinas, Nury Azpilcueta, María Teresa Valenzuela

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

El objetivo de este estudio fue evaluar el efecto de la incorporación de la vacuna antineumococica 10-valente (PCV 10) en la incidencia de la enfermedad neumocócica invasora (ENI) y en la neumonía adquirida en la comunidad (NAC) en niños hospitalizados menores de 5 años en el área sur de Santiago de Chile. Métodos. Se realizó un estudio ecológico de la incidencia de ENI y NAC en menores de 5 años del área sur de Santiago de Chile de 2009 a 2015. Las fuentes de información utilizadas fueron las de los laboratorios de bacteriología de cuatro hospitales, del Instituto de Salud Pública de Chile (ISP) y los registros de egresos hospitalarios. Resultados. Un total de 6 461 casos de NAC y 173 casos de ENI fueron confirmados por el ISP, de los cuales 169 casos fueron diagnosticados en los laboratorios de bacteriología de los hospitales incluidos en el estudio. Al comparar la incidencia de casos de 2010 frente a 2011- 2015, la razón de incidencias (RI) de ENI se redujo 10% anualmente (p = 0,026) y la de NAC, 8% en el mismo período (p <0,001). El total de días cama ocupados en el período 2009-2015 fue de 39 565 con una mediana de días cama ocupados entre 4 y 5. Hasta 2012 fallecieron 7 niños y desde entonces no ha habido fallecimientos por estas enfermedades. Conclusiones. La incorporación de la vacuna PCV-10 en el Programa Nacional de Inmunizaciones tuvo un efecto positivo, con una reducción significativa de las ENI y NAC y de la ocupación de camas por ENI y evitó casos y muertes.

Título traducido de la contribución	Impact of the 10-valent pneumococcal conjugate vaccine on the southern area of Santiago (Chile), 2009-2015
Idioma original	Español
Número de artículo	e155
Publicación	Revista Panamericana de Salud Publica/Pan American Journal of Public Health
Volumen	42
DOI	https://doi.org/10.26633/RPSP.2018.155
Estado	Publicada - 2018

Nota bibliográfica

Publisher Copyright:
© 2018 Pan American Health Organization. All rights reserved.

Palabras clave

Chile
Pneumococcal infections
Pneumococcal vaccine
Pneumonia
Streptococcus pneumoniae

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10.26633/RPSP.2018.155

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Alvarado, S., Cavada, G., Villena, R., Wilhelm, J., Budnik, I., Lara, C., Salinas, X., Azpilcueta, N., & Valenzuela, M. T. (2018). Efecto de la vacuna antineumocócica conjugada 10-valente en el área sur de Santiago de Chile, 2009-2015. Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 42, Artículo e155. https://doi.org/10.26633/RPSP.2018.155

@article{ca63a7d4705048dcacd1debcbaa5ee73,

title = "Efecto de la vacuna antineumoc{\'o}cica conjugada 10-valente en el {\'a}rea sur de Santiago de Chile, 2009-2015",

abstract = "Objective. The objective of this study was to evaluate the impact of the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) on the incidence of invasive pneumococcal disease (IPD) and on community-acquired pneumonia (CAP) in hospitalized children under 5 years of age in the southern area of Santiago, Chile. Methods. An ecological study was conducted on the incidence of IPD and CAP in children under age 5 in the southern area of Santiago (Chile) from 2009 to 2015. The information used was from bacteriology laboratories in four hospitals, the Chilean Institute of Health Public (ISP), and hospital discharge records. Results. A total of 6,461 cases of CAP and 173 cases of IPD were confirmed by the ISP; 169 of these cases were diagnosed in the bacteriology laboratories of the hospitals included in the study. When the incidence of cases in 2010 was compared to 2011-2015, the incidence ratio (IR) of IPD declined 10% annually (p=0.026) and CAP declined by 8% in the same period (p<0.001). Days of hospitalization due to IPD were reduced by 39% (p<0.001). Between 2009 and 2012, seven children died, but since then there have been no deaths due to these diseases. Conclusions. The introduction of the PCV-10 vaccine into the National Immunization Program has had a positive effect, with a significant reduction in IPD and CAP and in days of hospitalization due to IPD, while preventing cases and deaths.",

keywords = "Chile, Pneumococcal infections, Pneumococcal vaccine, Pneumonia, Streptococcus pneumoniae",

author = "Sylvina Alvarado and Gabriel Cavada and Rodolfo Villena and Jan Wilhelm and Isolda Budnik and Cristian Lara and Ximena Salinas and Nury Azpilcueta and Valenzuela, {Mar{\'i}a Teresa}",

year = "2018",

doi = "10.26633/RPSP.2018.155",

language = "Spanish",

volume = "42",

journal = "Revista Panamericana de Salud Publica/Pan American Journal of Public Health",

issn = "1020-4989",

publisher = "Pan American Health Organization",

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T1 - Efecto de la vacuna antineumocócica conjugada 10-valente en el área sur de Santiago de Chile, 2009-2015

AU - Alvarado, Sylvina

AU - Cavada, Gabriel

AU - Villena, Rodolfo

AU - Wilhelm, Jan

AU - Budnik, Isolda

AU - Lara, Cristian

AU - Salinas, Ximena

AU - Azpilcueta, Nury

AU - Valenzuela, María Teresa

PY - 2018

Y1 - 2018

N2 - Objective. The objective of this study was to evaluate the impact of the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) on the incidence of invasive pneumococcal disease (IPD) and on community-acquired pneumonia (CAP) in hospitalized children under 5 years of age in the southern area of Santiago, Chile. Methods. An ecological study was conducted on the incidence of IPD and CAP in children under age 5 in the southern area of Santiago (Chile) from 2009 to 2015. The information used was from bacteriology laboratories in four hospitals, the Chilean Institute of Health Public (ISP), and hospital discharge records. Results. A total of 6,461 cases of CAP and 173 cases of IPD were confirmed by the ISP; 169 of these cases were diagnosed in the bacteriology laboratories of the hospitals included in the study. When the incidence of cases in 2010 was compared to 2011-2015, the incidence ratio (IR) of IPD declined 10% annually (p=0.026) and CAP declined by 8% in the same period (p<0.001). Days of hospitalization due to IPD were reduced by 39% (p<0.001). Between 2009 and 2012, seven children died, but since then there have been no deaths due to these diseases. Conclusions. The introduction of the PCV-10 vaccine into the National Immunization Program has had a positive effect, with a significant reduction in IPD and CAP and in days of hospitalization due to IPD, while preventing cases and deaths.

AB - Objective. The objective of this study was to evaluate the impact of the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) on the incidence of invasive pneumococcal disease (IPD) and on community-acquired pneumonia (CAP) in hospitalized children under 5 years of age in the southern area of Santiago, Chile. Methods. An ecological study was conducted on the incidence of IPD and CAP in children under age 5 in the southern area of Santiago (Chile) from 2009 to 2015. The information used was from bacteriology laboratories in four hospitals, the Chilean Institute of Health Public (ISP), and hospital discharge records. Results. A total of 6,461 cases of CAP and 173 cases of IPD were confirmed by the ISP; 169 of these cases were diagnosed in the bacteriology laboratories of the hospitals included in the study. When the incidence of cases in 2010 was compared to 2011-2015, the incidence ratio (IR) of IPD declined 10% annually (p=0.026) and CAP declined by 8% in the same period (p<0.001). Days of hospitalization due to IPD were reduced by 39% (p<0.001). Between 2009 and 2012, seven children died, but since then there have been no deaths due to these diseases. Conclusions. The introduction of the PCV-10 vaccine into the National Immunization Program has had a positive effect, with a significant reduction in IPD and CAP and in days of hospitalization due to IPD, while preventing cases and deaths.

KW - Chile

KW - Pneumococcal infections

KW - Pneumococcal vaccine

KW - Pneumonia

KW - Streptococcus pneumoniae

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DO - 10.26633/RPSP.2018.155

M3 - Article

AN - SCOPUS:85111671632

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VL - 42

JO - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

JF - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

M1 - e155

ER -

Efecto de la vacuna antineumocócica conjugada 10-valente en el área sur de Santiago de Chile, 2009-2015

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