Detection of CD63+ micro-vesicles, placental alkaline phosphatase and angiogenic markers in gingival crevicular fluid in preeclamptic patients

Preeclampsia (PE) is a maternal disease that clinically manifests in the second half of pregnancy, characterized by hypertension accompanied by proteinuria and generalized edema. Its complications have become one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of premature births delivered before 35 weeks of gestation PE is present in around 5–10% of all pregnant women worldwide and despite the amount of resources invested in the research and treatment of this pathology, it’s still barely predictable and thus difficult to manage clinically. The aim of this study was to determine utility of Cd63+ micro-vesicles, placental alkaline phosphatase and angiogenic biomarkers concentrations in gingival crevicular fluid (GCF) as biomarkers of preeclampsia.