Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

188 Citas (Scopus)

Resumen

Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.

Idioma originalInglés
Páginas (desde-hasta)1817-1824
Número de páginas8
PublicaciónBiotechnology Letters
Volumen31
N.º12
DOI
EstadoPublicada - nov. 2009
Publicado de forma externa

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