Resumen
Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
Idioma original | Inglés |
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Páginas (desde-hasta) | 1825-1835 |
Número de páginas | 11 |
Publicación | Biotechnology Letters |
Volumen | 31 |
N.º | 12 |
Fecha en línea anticipada | 19 ago. 2009 |
DOI | |
Estado | Publicada - nov. 2009 |
Publicado de forma externa | Sí |