Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Manfred T. Reetz; Pankaj Soni; Juan Pablo Acevedo; Joaquin Sanchis

doi:10.1002/anie.200904209

Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Manfred T. Reetz
, Pankaj Soni
, Juan Pablo Acevedo
, Joaquin Sanchis

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

48 Citas (Scopus)

Resumen

Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

Idioma original	Inglés
Páginas (desde-hasta)	8268-8272
Número de páginas	5
Publicación	Angewandte Chemie - International Edition
Volumen	48
N.º	44
DOI	https://doi.org/10.1002/anie.200904209
Estado	Publicada - 19 oct. 2009
Publicado de forma externa	Sí

Acceder al documento

10.1002/anie.200904209

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{fe9a259fbefe4bf08b2c3c004e307da0,

title = "Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme",

abstract = "Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.",

keywords = "Directed evolution, Enzymes, Hydrogen bonds, Protein modifications, Saturation mutagenesis",

author = "Reetz, \{Manfred T.\} and Pankaj Soni and Acevedo, \{Juan Pablo\} and Joaquin Sanchis",

year = "2009",

month = oct,

day = "19",

doi = "10.1002/anie.200904209",

language = "English",

volume = "48",

pages = "8268--8272",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "44",

}

TY - JOUR

T1 - Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

AU - Reetz, Manfred T.

AU - Soni, Pankaj

AU - Acevedo, Juan Pablo

AU - Sanchis, Joaquin

PY - 2009/10/19

Y1 - 2009/10/19

N2 - Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

AB - Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

KW - Directed evolution

KW - Enzymes

KW - Hydrogen bonds

KW - Protein modifications

KW - Saturation mutagenesis

UR - https://www.scopus.com/pages/publications/70350110646

U2 - 10.1002/anie.200904209

DO - 10.1002/anie.200904209

M3 - Article

C2 - 19787674

AN - SCOPUS:70350110646

SN - 1433-7851

VL - 48

SP - 8268

EP - 8272

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

ER -

Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Resumen

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto