Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Manfred T. Reetz; Pankaj Soni; Juan Pablo Acevedo; Joaquin Sanchis

doi:10.1002/anie.200904209

Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Manfred T. Reetz, Pankaj Soni, Juan Pablo Acevedo, Joaquin Sanchis

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

43 Citas (Scopus)

Resumen

Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

Idioma original	Inglés
Páginas (desde-hasta)	8268-8272
Número de páginas	5
Publicación	Angewandte Chemie - International Edition
Volumen	48
N.º	44
DOI	https://doi.org/10.1002/anie.200904209
Estado	Publicada - 19 oct. 2009
Publicado de forma externa	Sí

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title = "Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme",

abstract = "Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.",

keywords = "Directed evolution, Enzymes, Hydrogen bonds, Protein modifications, Saturation mutagenesis",

author = "Reetz, {Manfred T.} and Pankaj Soni and Acevedo, {Juan Pablo} and Joaquin Sanchis",

year = "2009",

month = oct,

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AU - Reetz, Manfred T.

AU - Soni, Pankaj

AU - Acevedo, Juan Pablo

AU - Sanchis, Joaquin

PY - 2009/10/19

Y1 - 2009/10/19

N2 - Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

AB - Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

KW - Directed evolution

KW - Enzymes

KW - Hydrogen bonds

KW - Protein modifications

KW - Saturation mutagenesis

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U2 - 10.1002/anie.200904209

DO - 10.1002/anie.200904209

M3 - Article

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AN - SCOPUS:70350110646

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

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Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

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