TY - JOUR
T1 - Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus
AU - Corvalán R, Alejandro
AU - Akiba, Suminori
AU - Valenzuela B, María Teresa
AU - Cumsille G, Miguel Angel
AU - Koriyama, Chihaya
AU - Argandoña C, Jorge
AU - Backhouse E, Claudia
AU - Bal C, Matilde
AU - Mena U, Fernando
AU - Palma V, Mariana
AU - Eizuru, Yoshito
PY - 2005/11/22
Y1 - 2005/11/22
N2 - Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr virus.
AB - Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr virus.
KW - Epstein-Barr virus infections
KW - Herpes virus 4, human
KW - Stomach neoplasms
KW - Epstein-Barr virus infections
KW - Herpes virus 4, human
KW - Stomach neoplasms
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27744586586&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=27744586586&origin=inward
U2 - 10.4067/S0034-98872005000700001
DO - 10.4067/S0034-98872005000700001
M3 - Article
SN - 0034-9887
VL - 133
SP - 753
EP - 760
JO - Revista Medica de Chile
JF - Revista Medica de Chile
IS - 7
ER -
