Chikungunya, enfermedad emergente en América Latina.: Descripción de los primeros casos en Chile

Cecilia Perret Pérez; Cecilia Vizcaya; Thomas Weitzel; Reinaldo Rosas; Jeannette Dabanch; Constanza Martínez

doi:10.4067/s0716-10182018000400413

Chikungunya, enfermedad emergente en América Latina. Descripción de los primeros casos en Chile

Cecilia Perret Pérez^*, Cecilia Vizcaya, Thomas Weitzel, Reinaldo Rosas, Jeannette Dabanch, Constanza Martínez

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

Introducción:
Chikungunya (CHIK) se introduce en América el año 2013 diseminándose rápidamente. En 2014, se diagnosticó el primer caso importado en Chile.
Objetivos:
Identificar pacientes con sospecha clínica de CHIK. Describir sus características clínicas y laboratorio.
Pacientes y Métodos:
Se enrolaron pacientes con sospecha de CHIK. Se confirmó mediante reacción de polimerasa en cadena (RPC), IgM o IgG CHIKV. Se aplicó encuesta con preguntas demográficas, características del viaje, manifestaciones clínicas y laboratorio a pacientes y médicos tratantes.
Resultados:
Se enrolaron 21 pacientes, confirmando CHIK en 16 que se analizaron; 12 mujeres (75%), promedio edad 39 años (27-52). Exposición más frecuente fue el Caribe y Sudamérica. El síntoma inicial fue artralgia en 63%. Los síntomas más frecuentes fueron mialgias y malestar general (100%), fiebre y poliartralgia (94%). La mediana de duración de artralgias 90 días (3-262 días) y en 53% > 3 meses. Las articulaciones más comprometidas fueron tobillos, manos y muñecas, 87% con dolor invalidante. La artritis duró más en hombres que en mujeres (p < 0,001). El 38% de pacientes presentó linfopenia y un paciente trombocitopenia leve. Hubo dos hospitalizaciones por cefalea y pielonefritis aguda.
Conclusiones:
Chikungunya debe sospecharse en viajeros que regresan febriles y con poliartralgias intensas. Medidas de prevención deben ser indicadas a viajeros a zonas de riesgo.

Título traducido de la contribución	Chikungunya, emerging disease in Latin America. : Description of the first cases in Chile
Idioma original	Español
Páginas (desde-hasta)	413-419
Número de páginas	7
Publicación	Revista Chilena de Infectologia
Volumen	35
N.º	4
DOI	https://doi.org/10.4067/s0716-10182018000400413
Estado	Publicada - ago. 2018
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2018, Sociedad Chilena de Infectologia. All rights reserved.

Palabras clave

serie clínica
artropatía
Chikungunya
Chile
medicina del viajero
artralgia

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title = "Chikungunya, enfermedad emergente en Am{\'e}rica Latina.: Descripci{\'o}n de los primeros casos en Chile",

abstract = "Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and laboratory results. Results: 21 patients were enrolled and CHIK was confirmed in 16, who were further analyzed; 12 were female (75%), average age 39 years (27- 52). The Caribbean and South Americawere the most frequent sites of exposure. In 63%, the initial symptom was arthralgia. Most frequent symptoms were myalgias, malaise (both 100%), fever, and polyarthralgia (both 94%). The median duration of arthralgias was 90 days (3-262); in 53% arthralgias lasted ≥ 3 months. Main joints involved were ankles, hands, and wrists; 87% reported invalidating pain. Arthritis lasted longer in men than in women (p < 0.001). 38% of patients presented lymphopenia and one patient mild thrombocytopenia. Two patients required hospitalization, one with severe headaches, the other with acute pyelonephritis. Conclusions: Chikungunya should be suspected in returning travelers presenting with fever and severe polyarthralgia. Travelers to endemic areas should apply prevention measures to avoid mosquito bites.",

keywords = "serie cl{\'i}nica, artropat{\'i}a, Chikungunya, Chile, medicina del viajero, artralgia, Chikungunya, Chile, arthropathy, clinical cases, travel medicine, arthralgia",

author = "P{\'e}rez, {Cecilia Perret} and Cecilia Vizcaya and Thomas Weitzel and Reinaldo Rosas and Jeannette Dabanch and Constanza Mart{\'i}nez",

year = "2018",

month = aug,

doi = "10.4067/s0716-10182018000400413",

language = "Spanish",

volume = "35",

pages = "413--419",

journal = "Revista Chilena de Infectologia",

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T1 - Chikungunya, enfermedad emergente en América Latina.

T2 - Descripción de los primeros casos en Chile

AU - Pérez, Cecilia Perret

AU - Vizcaya, Cecilia

AU - Weitzel, Thomas

AU - Rosas, Reinaldo

AU - Dabanch, Jeannette

AU - Martínez, Constanza

PY - 2018/8

Y1 - 2018/8

N2 - Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and laboratory results. Results: 21 patients were enrolled and CHIK was confirmed in 16, who were further analyzed; 12 were female (75%), average age 39 years (27- 52). The Caribbean and South Americawere the most frequent sites of exposure. In 63%, the initial symptom was arthralgia. Most frequent symptoms were myalgias, malaise (both 100%), fever, and polyarthralgia (both 94%). The median duration of arthralgias was 90 days (3-262); in 53% arthralgias lasted ≥ 3 months. Main joints involved were ankles, hands, and wrists; 87% reported invalidating pain. Arthritis lasted longer in men than in women (p < 0.001). 38% of patients presented lymphopenia and one patient mild thrombocytopenia. Two patients required hospitalization, one with severe headaches, the other with acute pyelonephritis. Conclusions: Chikungunya should be suspected in returning travelers presenting with fever and severe polyarthralgia. Travelers to endemic areas should apply prevention measures to avoid mosquito bites.

AB - Background: Chikungunya (CHIK) was introduced in The Americas in 2013, spreading rapidly. In 2014, the first imported case was diagnosed in Chile. Aim: To identify patients with clinical suspicion of CHIK and describe their clinical and laboratory characteristics. Patients and Methods: Patients with suspected CHIK were enrolled. All were confirmed by PCR, IgM or IgG CHIK. A structured survey was applied, which included demographic questions, travel characteristics, clinical manifestations, and laboratory results. Results: 21 patients were enrolled and CHIK was confirmed in 16, who were further analyzed; 12 were female (75%), average age 39 years (27- 52). The Caribbean and South Americawere the most frequent sites of exposure. In 63%, the initial symptom was arthralgia. Most frequent symptoms were myalgias, malaise (both 100%), fever, and polyarthralgia (both 94%). The median duration of arthralgias was 90 days (3-262); in 53% arthralgias lasted ≥ 3 months. Main joints involved were ankles, hands, and wrists; 87% reported invalidating pain. Arthritis lasted longer in men than in women (p < 0.001). 38% of patients presented lymphopenia and one patient mild thrombocytopenia. Two patients required hospitalization, one with severe headaches, the other with acute pyelonephritis. Conclusions: Chikungunya should be suspected in returning travelers presenting with fever and severe polyarthralgia. Travelers to endemic areas should apply prevention measures to avoid mosquito bites.

KW - serie clínica

KW - artropatía

KW - Chikungunya

KW - Chile

KW - medicina del viajero

KW - artralgia

KW - Chikungunya

KW - Chile

KW - arthropathy

KW - clinical cases

KW - travel medicine

KW - arthralgia

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U2 - 10.4067/s0716-10182018000400413

DO - 10.4067/s0716-10182018000400413

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