Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions: An update on therapeutic strategies

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Córdova, Capucine Trollet, Claudio Cabello-Verrugio*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

15 Citas (Scopus)

Resumen

Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.

Idioma originalInglés
Páginas (desde-hasta)1189-1200
Número de páginas12
PublicaciónCurrent Protein and Peptide Science
Volumen19
N.º12
DOI
EstadoPublicada - 2018
Publicado de forma externa

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© 2018 Bentham Science Publishers.

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