Bacterial endotoxin and tumor necrosis factor stimulate prostaglandin production by human decidua

R. Romero*, M. Mazor, Y. K. Wu, C. Avila, E. Oyarzun, M. D. Mitchell

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

116 Citas (Scopus)

Resumen

The purpose of these studies was to determine the effect of bacterial endotoxin and tumor necrosis factor (TNF) on prostaglandin (PG) secretion by human decidua. Decidual explants were established from women undergoing elective cesarean sections before the onset of labor. Escherichia Coli endotoxin and purified human recombinant TNF (rhTNF) were incubated with decidual explants. PGF and PGF2 biosynthesis was measured by radioimmunoassay. A significant increase in the release of all PGs into the media occurred in response to LPS and TNF. In the setting of an extraamniotic infection, bacterial and host secretory products (TNF) could trigger the onset of labor, activating the decidua to produce PGs.

Idioma originalInglés
Páginas (desde-hasta)183-186
Número de páginas4
PublicaciónProstaglandins Leukotrienes and Essential Fatty Acids
Volumen37
N.º3
DOI
EstadoPublicada - sep 1989
Publicado de forma externa

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