Antimicrobial capacity of Leucocyte-and Platelet Rich Fibrin against periodontal pathogens

Ana B. Castro*, Esteban R. Herrero, Vera Slomka, Nelson Pinto, Wim Teughels, Marc Quirynen

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

44 Citas (Scopus)


Various studies have described the biological properties of the Leucocyte- and Platelet Rich Fibrin (L-PRF) such as the antimicrobial effect against wound bacteria, but less is known about the effect against periodontal pathogens. The aim of this study was to evaluate the antibacterial properties of the L-PRF membrane and L-PRF exudate against the main periopathogens cultured on agar plates and in planktonic solution. This study demonstrated the antibacterial effect of the L-PRF membrane against P. intermedia, F. nucleatum, and A. actinomycetemcomitans, but especially against P. gingivalis. The L-PRF exudate also showed a strong inhibition against P. gingivalis on agar plates. No inhibition could be observed for the other bacterial strains. Moreover, L-PRF exudate decreased the number of viable P.gingivalis in a planktonic solution in a dose-dependent way. However, A. actinomycetemcomitans showed an increased growth in planktonic solution when in contact with the L-PRF exudate.
Idioma originalInglés
Número de artículo8188
PublicaciónScientific Reports
EstadoPublicada - 1 dic. 2019

Nota bibliográfica

Publisher Copyright:
© 2019, The Author(s).

Palabras clave

  • Actinobacillus-actinomycetemcomitans
  • Dental plaque
  • Plasma
  • Growth
  • Coaggregation
  • Gingipains
  • Therapies
  • Biofilm
  • Rhbmp-2


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