Enfermedad celíaca y su patogenia

María José Herrera, Marcela A. Hermoso, Rodrigo Quera*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

5 Citas (Scopus)

Resumen

Celiac disease (CD), with a 1% world-wide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, that codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis (IELs) and leukocyte infiltration of the lamina propria. Patients achieve a complete clinical and endoscopic remission with a gluten free diet. However, symptoms and anatomical alterations recur when this protein is reintroduced in the diet. The pathogenic mechanisms in this disease are not yet well understood, but it is clear that genetic, environmental and immunological factors play a role. The latter are the focus of this review, since this is the only autoimmune disease whose precipitating factor for immunological tissue damage is known.

Título traducido de la contribuciónAn update on the pathogenesis of celiac disease
Idioma originalEspañol
Páginas (desde-hasta)1617-1626
Número de páginas10
PublicaciónRevista Medica de Chile
Volumen137
N.º12
EstadoPublicada - dic 2009
Publicado de forma externa

Palabras clave

  • Celiac disease
  • Gliadin
  • HLA-D antigens

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