Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: comunicación preliminar

Título traducido de la contribución: An ultrasound score to predict the presence of papillary thyroid carcinoma. Preliminary report

José Miguel Domínguez, René Baudrand, Eugenio Arteaga, Claudia Campusano, Gilberto González, Lorena Mosso, Gabriel Cavada, Francisco Cruz, Javiera Torres, Antonieta Solar, Tatiana Arias, Alejandra Pizarro, Marcelo Gómez, Carlos Fardella*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

Background: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim: To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. Material and methods: Retrospective review of all fine needle aspiration biopsies of the thyroid performed in a lapse of two years. Biopsies that were conclusive for PTC were selected and compared with an equal amount of randomly selected biopsies that disclosed a benign diagnosis. Results: One hundred twenty two biopsies of a total of 1,498 were conclusive for PTC. Univariate analysis showed associations with PTC for the presence of micro-calcifications (Odds ratio (OR) 49.2: 95% confidence intervals (CI) 18.7-140.9), solid predominance (OR 25.1; 95% CI 6-220), hypoechogenicity (OR 23.5, 95% CI 6.5-122.6), irregular borders (OR 17, 95% CI 7.2-42.9), lymph node involvement (OR 12.3, 95% CI 2.7-112), central vascularization (OR 12.2, 95% CI 4.8-33.3), local invasion and hyperechogenicity (OR 0.2; CI 95% CI 0.03-0.6). Multivariate analysis disclosed microcalcifications (OR 28.1; CI 95% 8.9-89), hypoechogenicity (OR 9.4; 95% CI 1.5-59.5) and irregular borders (OR 4.7; CI 95% 1.5-15) as the variables independently associated with the presence of PTC. The prevalence of PTC in the presence of the three variables was 97.6% (Likelihood ratio (LR) 45) and 5.4% in their absence (LR 0.06). Conclusions: This scale predicts the presence or absence of PTC using simple ultrasound characteristics.
Título traducido de la contribuciónAn ultrasound score to predict the presence of papillary thyroid carcinoma. Preliminary report
Idioma originalEspañol
Páginas (desde-hasta)1031-1036
Número de páginas6
PublicaciónRevista Medica de Chile
Volumen137
N.º8
EstadoPublicada - ago. 2009

Palabras clave

  • Biopsy
  • Carcinoma
  • Fine-needle
  • Papillary
  • Thyroid neoplasms

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