Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity

Andrés A. Herrada, Francisco J. Contreras, Natacha P. Marini, Cristian A. Amador, Pablo A. González, Claudia M. Cortés, Claudia A. Riedel, Cristián A. Carvajal, Fernando Figueroa, Luis F. Michea, Carlos E. Fardella, Alexis M. Kalergis

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

143 Citas (Scopus)


Excessive production of aldosterone leads to the development of hypertension and cardiovascular disease by generating an inflammatory state that can be promoted by T cell immunity. Because nature and intensity of T cell responses is controlled by dendritic cells (DCs), it is important to evaluate whether the function of these cells can be modulated by aldosterone. In this study we show that aldosterone augmented the activation of CD8+ T cells in a DC-dependent fashion. Consistently, the mineralocorticoid receptor was expressed by DCs, which showed activation of MAPK pathway and secreted IL-6 and TGF-β in response to aldosterone. In addition, DCs stimulated with aldosterone impose a Th17 phenotype to CD4+ T cells, which have recently been associated with the promotion of inflammatory and autoimmune diseases. Accordingly, we observed that aldosterone enhances the progression of experimental autoimmune encephalomyelitis, an autoimmune disease promoted by Th17 cells. In addition, blockade of the mineralocorticoid receptor prevented all aldosterone effects on DCs and attenuated experimental autoimmune encephalomyelitis development in aldosterone-treated mice. Our data suggest that modulation of DC function by aldosterone enhances CD8+ T cell activation and promotes Th17-polarized immune responses, which might contribute to the inflammatory damage leading to hypertension and cardiovascular disease.
Idioma originalInglés
Páginas (desde-hasta)191-202
Número de páginas12
PublicaciónJournal of Immunology
EstadoPublicada - 1 ene. 2010

Nota bibliográfica

Copyright © 2009 by The American Association of Immunologists, Inc.


Profundice en los temas de investigación de 'Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity'. En conjunto forman una huella única.

Citar esto