Terapia de inducción acelerada con infliximab en paciente con colitis ulcerosa grave refractaria a corticoides. Caso clinic

Daniela Fluxá, Lilian Flores, Udo Kronberg, Mauricio Moreno, Carolina Figueroa, Patricio Ibáñez, Jaime Lubascher, Daniela Simian, Rodrigo Quera*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Acute severe ulcerative colitis (ASUC) is a potentially life-threatening condition that requires early recognition, hospitalization and adequate treatment. Currently, the use of infliximab in ulcerative colitis (UC) is recommended in the case of severe disease refractory to corticosteroids, once that superimposed bacterial or viral infections (such as cytomegalovirus or Clostridium difficile) have been excluded. However, conventional weight-based regimens of infliximab might be insufficient for patients with ASUC. Accelerated infliximab induction regimen may increase its serum concentration levels and efficacy by reducing early colectomy rates in these patients. We report a 34 year old female presenting with an ASUC. She was initially treated with hydrocortisone 300 mg/day and mesalazine enemas 4 g/day with an unfavorable clinical response. At the fifth day of therapy, an accelerated induction therapy with infliximab was started in doses of 10 mg/kg at weeks 0, 1 and 4. After the second dose, there was a favorable response with reduction of abdominal pain, stool frequency and hematochezia. She was discharged with prednisone and azathioprine. After a year of starting infliximab, the patient remains in clinical remission.

Título traducido de la contribuciónAcute severe ulcerative colitis treated with accelerated infliximab induction. Case report
Idioma originalEspañol
Páginas (desde-hasta)1083-1088
Número de páginas6
PublicaciónRevista Medica de Chile
Volumen145
N.º8
DOI
EstadoPublicada - 2017
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2017, Sociedad Medica de Santiago. All rights reserved.

Palabras clave

  • Colitis
  • Infliximab
  • Time-To-treatment
  • Ulcerative

Huella

Profundice en los temas de investigación de 'Terapia de inducción acelerada con infliximab en paciente con colitis ulcerosa grave refractaria a corticoides. Caso clinic'. En conjunto forman una huella única.

Citar esto