A potential role for epidermal growth factor/α-transforming growth factor in human parturition

Roberto Romero*, Ying King Wu, Enrique Oyarzun, John C. Hobbins, Murray D. Mitchell

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

43 Citas (Scopus)

Resumen

Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E2. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E2 into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.

Idioma originalInglés
Páginas (desde-hasta)55-60
Número de páginas6
PublicaciónEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volumen33
N.º1
DOI
EstadoPublicada - oct 1989
Publicado de forma externa

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