TY - JOUR
T1 - A novel self-assembled liposome-based polymeric hydrogel for cranio-maxillofacial applications
T2 - Preliminary findings
AU - Joo, Victor
AU - Ramasamy, Thiruganesh
AU - Haidar, Ziyad S.
PY - 2011/6
Y1 - 2011/6
N2 - Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or 'layer-by-layer' which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.
AB - Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or 'layer-by-layer' which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.
KW - Amphiphilic copolymers
KW - Biomedicine
KW - Bone regeneration
KW - Core-shell
KW - Dentistry
KW - Drug delivery
KW - Liposomes
KW - Nanogel
KW - Nanoncology
KW - Nanoshell
KW - Polymer
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=79960190595&partnerID=8YFLogxK
U2 - 10.3390/polym3020967
DO - 10.3390/polym3020967
M3 - Article
AN - SCOPUS:79960190595
VL - 3
SP - 967
EP - 974
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 2
ER -