TY - JOUR
T1 - ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD
AU - Henríquez-Henríquez, Marcela
AU - Solari, Sandra
AU - Várgas, Gisela
AU - Vásquez, Luis
AU - Allende, Fidel
AU - Carla Castañón, S.
AU - Tenorio, Marcela
AU - Gutiérrez, Teresa Quiroga
N1 - Publisher Copyright:
© The Author(s) 2012.
PY - 2015/11
Y1 - 2015/11
N2 - Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.
AB - Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.
KW - ADHD
KW - Endophenotype
KW - LC-PUFAs
KW - W-3
UR - http://www.scopus.com/inward/record.url?scp=84943526504&partnerID=8YFLogxK
U2 - 10.1177/1087054712461175
DO - 10.1177/1087054712461175
M3 - Article
C2 - 23100268
AN - SCOPUS:84943526504
SN - 1087-0547
VL - 19
SP - 977
EP - 986
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 11
ER -