κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Ramiro Freudenthal, Fernando Locatelli, Gabriela Hermitte, Héctor Maldonado, Carlos Lafourcade, Alejandro Delorenzi, Arturo Romano*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

82 Citas (Scopus)

Resumen

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.

Idioma originalInglés
Páginas (desde-hasta)143-146
Número de páginas4
PublicaciónNeuroscience Letters
Volumen242
N.º3
DOI
EstadoPublicada - 20 feb. 1998
Publicado de forma externa

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