TY - JOUR
T1 - Wasting is associated with stunting in early childhood
AU - Richard, Stephanie A.
AU - Black, Robert E.
AU - Gilman, Robert H.
AU - Guerrant, Richard L.
AU - Kang, Gagandeep
AU - Lanata, Claudio F.
AU - Mølbak, Käre
AU - Rasmussen, Zeba A.
AU - Sack, R. Bradley
AU - Valentiner-Branth, Palle
AU - Checkley, William
AU - Moore, Sean R.
AU - Lima, Aldo A.M.
AU - Pinkerton, Relana C.
AU - Aaby, Peter
AU - Cabrera, Lilia Z.
AU - Bern, Caryn
AU - Sterling, Charles R.
AU - Epstein, Leonardo D.
AU - Moulton, Lawrence
AU - Perch, Michael
AU - Fischer, Thea K.
AU - Sommerfelt, Halvor
AU - Steinsland, Hans
AU - Verastegui, Hector
PY - 2012/7
Y1 - 2012/7
N2 - The longitudinal relationship between stunting and wasting in children is poorly characterized. Instances of wasting or poor weight gain may precede linear growth retardation. We analyzed longitudinal anthropometric data for 1599 children from 8 cohort studies to determine the effect of wasting [weight-for-length Z-score (WLZ) <-2] and variability in WLZ in the first 17 mo on length-for-age Z-score (LAZ) at 18-24 mo of age. In addition, we considered the effects of change in WLZ during the previous 6-mo period on length at 18 and 24 mo. Wasting at 6-11 or 12-17 mo was associated with decreased LAZ; however, children who experienced wasting only at 0-5 mo did not suffer any long-term growth deficits compared with children with no wasting during any period. Children with greater WLZ variability (≥0.5 SD) in the first 17 mo of life were shorter [LAZ = -0.51 SD (95% CI: -0.67, 20.36 SD)] at 18-24 mo of age than children with WLZ variability <0.5. Change in WLZ in the previous 6-mo period was directly associated with greater attained length at 18 mo [0.33 cm (95% CI: 0.11, 0.54 cm)] and 24 mo [0.72 cm (95% CI: 0.52, 0.92 cm)]. Children with wasting, highly variable WLZ, or negative changes in WLZ are at a higher risk for linear growth retardation, although instances of wasting may not be the primary cause of stunting in developing countries.
AB - The longitudinal relationship between stunting and wasting in children is poorly characterized. Instances of wasting or poor weight gain may precede linear growth retardation. We analyzed longitudinal anthropometric data for 1599 children from 8 cohort studies to determine the effect of wasting [weight-for-length Z-score (WLZ) <-2] and variability in WLZ in the first 17 mo on length-for-age Z-score (LAZ) at 18-24 mo of age. In addition, we considered the effects of change in WLZ during the previous 6-mo period on length at 18 and 24 mo. Wasting at 6-11 or 12-17 mo was associated with decreased LAZ; however, children who experienced wasting only at 0-5 mo did not suffer any long-term growth deficits compared with children with no wasting during any period. Children with greater WLZ variability (≥0.5 SD) in the first 17 mo of life were shorter [LAZ = -0.51 SD (95% CI: -0.67, 20.36 SD)] at 18-24 mo of age than children with WLZ variability <0.5. Change in WLZ in the previous 6-mo period was directly associated with greater attained length at 18 mo [0.33 cm (95% CI: 0.11, 0.54 cm)] and 24 mo [0.72 cm (95% CI: 0.52, 0.92 cm)]. Children with wasting, highly variable WLZ, or negative changes in WLZ are at a higher risk for linear growth retardation, although instances of wasting may not be the primary cause of stunting in developing countries.
UR - http://www.scopus.com/inward/record.url?scp=84863541714&partnerID=8YFLogxK
U2 - 10.3945/jn.111.154922
DO - 10.3945/jn.111.154922
M3 - Article
C2 - 22623393
AN - SCOPUS:84863541714
SN - 0022-3166
VL - 142
SP - 1291
EP - 1296
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 7
ER -