Vitamin D and parathyroid hormone levels and bone mineral density in patients undergoing hematopoietic cell transplantation: Un nuevo problema a considerar

V. Pablo Florenzano, Daniel Ernst, Nicole Lustig, Patricio Rojas, Pablo Ramírez, Claudia Campusano

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.

Translated title of the contributionVitamin D and parathyroid hormone levels and bone mineral density in patients undergoing hematopoietic cell transplantation
Original languageSpanish
Pages (from-to)1119-1124
Number of pages6
JournalRevista Medica de Chile
Volume144
Issue number9
DOIs
StatePublished - Sep 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016, Sociedad Medica de Santiago. All rights reserved.

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