Vigilancia de laboratorio de Streptococcus pneumoniae procedente de enfermedad invasora, Chile 2007-2012

Translated title of the contribution: Laboratory surveillance of Streptococcus pneumoniae from invasive disease, Chile 2007-2012

M. Teresa Valenzuela, Mabel Seoane, Andrea Canals, Paola Pidal, Juan C. Hormazábal, Pamela Araya, Solana Terrazas, Janepsy Díaz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: 10-valent pneumococcal vaccine (PCV-10) was introduced in 2011 to the National Immunization Program in Chile. It was administered in 4 doses, but in 2012 it was modified to a 3 dose program. This article shows the results of the Laboratory Surveillance System for Streptococcus pneumoniae isolated of invasive disease from 2007 to 2012 and compares the incidence of invasive pneumococcal disease (IPD) by age groups in the prevaccinal (2007-2010) and postvaccinal period (2012). Methods: Descriptive study of S. pneumoniae surveillance in invasive diseases cases confirmed at the National Reference Laboratory of the Institute of Public Health of Chile from 2007 to 2012. Results: Global incidence of laboratory confirmed IPD cases decreased 27.8% from 2007 to 2012 and showed a lower risk for IPD in 2012 compared with 2007. Incidence in children aged 1 year or less decreased from 56.1 to 16.3 per 100,000 and from 42.0 to 19.9 per 100,000 in children aged 12 to 23 months in the same period. Highest decreases were observed in IPD cases caused by serotypes 4 (100%), 19F (93.3%), 23F (90.9%), 14 (81.1%), 6B (70%), 18C (58.3%) and 1(81.8%) in children aged 2 years or less. Conclusion: Surveillance System detects S. pneumoniae isolated from invasive diseases, contributing with information about laboratory confirmed IPD trends, prevalent serotypes and replacement effects. These results can be used as evidence in healthcare decision making for pneumococcal vaccines.

Translated title of the contributionLaboratory surveillance of Streptococcus pneumoniae from invasive disease, Chile 2007-2012
Original languageSpanish
Pages (from-to)651-658
Number of pages8
JournalRevista Chilena de Infectologia
Issue number6
StatePublished - 2014

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© 2014, Sociedad Chilena de Infectologia. All rights reserved.


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