Viable Pregnancy in a patient with metastatic melanoma treated with double checkpoint immunotherapy

Mauricio Burotto, Juan G. Gormaz, Suraj Samtani, Nicolas Valls, Ricardo Silva, Carlos Rojas, Sergio Portiño, Carlos de la Jara

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Metastatic cancers during pregnancy have historically been associated with dismal outcomes, with greater rates of tumor progression in part because of diminished treatment alternatives. Immunotherapy with T-cell checkpoint inhibitors has significantly impacted the survival of several metastatic tumors. However, given their mechanism of action, immune-related adverse events can occur, especially with combined immunotherapy treatments. During pregnancy, checkpoint pathways have a major role, providing immune tolerance to the fetal allograft. Furthermore, evidence suggests that inhibition of this pathway may be associated with an increased risk of miscarriage. We describe, to our knowledge, the first case reported in the literature of a patient 7 weeks pregnant, diagnosed with metastatic melanoma and treated with nivolumab plus ipilimumab. We also present the associated immune-related side effects and their treatment, as well as the oncologic results that lead to favorable pregnancy outcome.
Original languageAmerican English
Pages (from-to)164-169
Number of pages6
JournalSeminars in Oncology
Volume45
Issue number3
DOIs
StatePublished - 1 Jun 2018
Externally publishedYes

Keywords

  • brain metastases
  • cancer
  • clinical manifestations
  • prognosis

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