Vascular Endothelial Growth Factors in Tissue Engineering: Challenges and Prospects for Therapeutic Angiogenesis

Ekaterina S. Lifirsu; Murugan Ramalingam; Ziyad S. Haidar

doi:10.1002/9781118371183.ch11

Vascular Endothelial Growth Factors in Tissue Engineering: Challenges and Prospects for Therapeutic Angiogenesis

Ekaterina S. Lifirsu^*, Murugan Ramalingam, Ziyad S. Haidar

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Technologies enhancing tissue vascularity are critically important to cardiovascular medicine. Currently, strategies to promote angiogenesis and arteriogenesis in a controlled manner are limited. This chapter discusses the role and promise of vascular endothelial growth factor (VEGF), in hard/soft tissue engineering applications, primarily focusing on therapeutic angiogenesis. A brief review of the different delivery systems, ranging from scaffolds to nanoparticles, carrying VEGF follows, in the context of present potential and challenges. Finally, a prospectus on the future of VEGF therapy will be presented.

Original language	English
Title of host publication	Integrated Biomaterials in Tissue Engineering
Publisher	John Wiley and Sons
Pages	275-293
Number of pages	19
ISBN (Print)	9781118311981
DOIs	https://doi.org/10.1002/9781118371183.ch11
State	Published - 4 Apr 2012
Externally published	Yes

Bibliographical note

Keywords

Hard tissues
Soft tissues
Therapeutic angiogenesis
Tissue engineering
Vascular endothelial growth factors

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10.1002/9781118371183.ch11

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abstract = "Technologies enhancing tissue vascularity are critically important to cardiovascular medicine. Currently, strategies to promote angiogenesis and arteriogenesis in a controlled manner are limited. This chapter discusses the role and promise of vascular endothelial growth factor (VEGF), in hard/soft tissue engineering applications, primarily focusing on therapeutic angiogenesis. A brief review of the different delivery systems, ranging from scaffolds to nanoparticles, carrying VEGF follows, in the context of present potential and challenges. Finally, a prospectus on the future of VEGF therapy will be presented.",

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AU - Haidar, Ziyad S.

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AB - Technologies enhancing tissue vascularity are critically important to cardiovascular medicine. Currently, strategies to promote angiogenesis and arteriogenesis in a controlled manner are limited. This chapter discusses the role and promise of vascular endothelial growth factor (VEGF), in hard/soft tissue engineering applications, primarily focusing on therapeutic angiogenesis. A brief review of the different delivery systems, ranging from scaffolds to nanoparticles, carrying VEGF follows, in the context of present potential and challenges. Finally, a prospectus on the future of VEGF therapy will be presented.

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KW - Soft tissues

KW - Therapeutic angiogenesis

KW - Tissue engineering

KW - Vascular endothelial growth factors

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PB - John Wiley and Sons

ER -

Vascular Endothelial Growth Factors in Tissue Engineering: Challenges and Prospects for Therapeutic Angiogenesis

Abstract

Bibliographical note

Keywords

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