Vascular Endothelial Growth Factors in Tissue Engineering: Challenges and Prospects for Therapeutic Angiogenesis

Ekaterina S. Lifirsu, Murugan Ramalingam, Ziyad Haidar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Technologies enhancing tissue vascularity are critically important to cardiovascular medicine. Currently, strategies to promote angiogenesis and arteriogenesis in a controlled manner are limited. This chapter discusses the role and promise of vascular endothelial growth factor (VEGF), in hard/soft tissue engineering applications, primarily focusing on therapeutic angiogenesis. A brief review of the different delivery systems, ranging from scaffolds to nanoparticles, carrying VEGF follows, in the context of present potential and challenges. Finally, a prospectus on the future of VEGF therapy will be presented.

Original languageEnglish
Title of host publicationIntegrated Biomaterials in Tissue Engineering
PublisherJohn Wiley and Sons
Pages275-293
Number of pages19
ISBN (Print)9781118311981
DOIs
StatePublished - 4 Apr 2012
Externally publishedYes

Keywords

  • Hard tissues
  • Soft tissues
  • Therapeutic angiogenesis
  • Tissue engineering
  • Vascular endothelial growth factors

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