Vaginal misoprostol and cervical ripening balloon for induction of labor in late-term pregnancies

Jorge Duro Gómez, María Fernanda Garrido Oyarzún, Ana Belén Rodríguez Marín, Antonio Jesús de la Torre González, José Eduardo Arjona Berral, Camil Castelo-Branco

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Methods: This open, quasi-experimental, prospective study included 109 nulliparous women with late-term pregnancies and Bishop scores < 7. Fifty-five women were allocated to receive vaginal misoprostol 25 mcg and 54 received the CCRB to induce labor. The primary outcome was the time until delivery. Secondary outcomes included time to the onset of labor and obstetric and perinatal outcomes. Results: Women in the misoprostol group experienced shorter time until delivery (25.41 h vs 31.26 h; P < 0.01) and in a greater percentage gave birth within the first 24 h. Time to active stage of labor was 19.5 h and 23.8 h (P < 0.01) for misoprostol and the CCRB, respectively. There were no differences in the rates of cesarean section or post-partum anemia. Additionally, there were no differences in rates of tachysystolia, intrapartum fever, or meconium. Perinatal outcomes, post-partum pH, Apgar scores, and neonatal admissions were similar in the two groups. Conclusion: Misoprostol 25 mcg reduces labor induction time compared with the CCRB with similar safety in late-term pregnancies.
Original languageAmerican English
Pages (from-to)87-91
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Issue number1
StatePublished - 1 Jan 2017


  • balloon catheter
  • cervical ripening
  • labor induction
  • misoprostol
  • perinatal outcomes


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