Uso de concentrados de fibrinógeno para el tratamiento de la hipofibrinogenemia adquirida

Translated title of the contribution: Use of fibrinogen concentrates for the treatment of acquired hypofibrinogenemia

Ignacio Alonso Sarmiento Goldberg, David Torres Pérez*, Tiare de la Puente Bernácer, Mario Portilla Flores, Mauricio González Luza

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: An adequate bleeding management should include a proper assessment of fibrinogen values and consequent replacement. Traditional sources for this hemostatic element include fresh frozen plasma and cryoprecipitates. Lyophilized human fibrinogen concentrates are a novel therapeutic alter-native for the chilean market. Aim: This study aims to describe the clinical course of the first patients in our institution receiving fibrinogen concentrates, included in a goal directed hemostatic management algorithm. Materials and Method: Case series of patients with hypofibrinogenemia secondary to severe perioperative bleeding, in which fibrinogen concentrate was used for fibrinogen replacement. Thromboelastometry was used to define dose regimens. Demographic and surgical variables, complications and follow-up up to 3 months were registered. Results: Fibrinogen concentrate was used in 18 patients. Median age was 40.7 (56.5-63) years, and two thirds of the patients were male. Five patients died. All of the cases required postoperative intensive care. Eight patients underwent cardiac surgery. There was a heterogenic use of blood derived products and lyophilized concentrates, but in all cases its use was guided by thromboelastometry. No patients needed a secondary exploration due to bleeding. Conclusion: The use of human fibrinogen concentrate included in a bleeding management algorithm is a feasible hemostatic resource in the chilean current situation. The clinical impact of this intervention requires further evidence-based evaluation.

Translated title of the contributionUse of fibrinogen concentrates for the treatment of acquired hypofibrinogenemia
Original languageSpanish
Pages (from-to)703-709
Number of pages7
JournalRevista de Cirugia
Issue number6
StatePublished - 2021

Bibliographical note

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© 2021, Sociedad de Cirujanos de Chile. All rights reserved.


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