Usefulness of the measurement of insulin-like growth factor 1 (IGF-I) and IGF-1 binding protein-3 (IGFBP-3) for the diagnosis of growth hormone (GH) deficiency in children

Ethel Codner D, Verónica Méricq G., Francisca Ugarte P, Germán Iñíguez V, Marcela Espinoza F, Alejandra Avila A, Teresa Salazar C, Fernando Cassorla G, Hernán García B

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5 Scopus citations

Abstract

Background: The diagnosis of GH deficiency (GIlD) is based upon the results of GH stimulation tests, which have several drawbacks. Aim: To evaluate the usefulness of IGP-1 and IGFBP-3 for the diagnosis of GHD in prepuberal children. Material and methods: We measured IGP-1 and IGFBP-3 in three group of subjects: I. GHD (n:24), height <-2SD for age (Z score, average ± SD: -4.2 ± 1.2), growth velocity <p10 (3.4 ± 1,0 cm/year) and peak GH level on two GH stimulation tests <7 ng/ml (1.2 ± 0.6 ng/ml); II. Short non-GHD (NGHD, n:32), height of -2.7 ± 0.9 SD for age, growth velocity <p 25 (3.9 ± 1.2 cm/year), and peak GH level on two GH stimulation tests >7 ng/ml (15.3 ± 6.9 ng/ml), y III. Normal school children (n:35) with normal heights (-0.17 ± 0.12 SD) were studied as controls. Results: IGP-1 and IGFBP-3 were significantly lower in GHD than in NGHD and controls (p <0.001), and in NGHD than in C (p <0.001). We defined the normal range of both proteins as ±2 SD of the mean of the control group. Using this criteria, IGP-I was low in 21/24 GHD, and in 12/32 NGHD. IGFBP-3 was low in 22/24 GHD, and in 6/32 NGHD. Only 1 GHD patient had both exams in the normal range, suggesting that he is probably NGHD. 4/32 of the NGHD had both exams below normal range, suggesting that they are probably GHD. Conclusions: IGF-1 and IGFBP-3 are important tools for the diagnosis of GHD.

Translated title of the contributionUsefulness of the measurement of insulin-like growth factor 1 (IGF-I) and IGF-1 binding protein-3 (IGFBP-3) for the diagnosis of growth hormone (GH) deficiency in children
Original languageSpanish
Pages (from-to)807-813
Number of pages7
JournalRevista Medica de Chile
Volume127
Issue number7
StatePublished - Jul 1999
Externally publishedYes

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