Use of PRF in combination with synthetic filling materials (HA and ß-TCP) for bone reconstructions

M. Parra, Z. S. Haidar, Sergio Olate

Research output: Contribution to journalArticlepeer-review


.. All rights reserved. Introduction: Reconstructive surgeries of the alveolar process using bone grafts are frequent, with the gold standard in bone grafts continues today to be autogenous bone; despite its known limitations, requiring the continuous development of new materials and alternatives, such as synthetic grafts, mainly those based on hydroxyapatite or beta tricalcium phosphate. Yet, are mainly osteoconductive; hence, the use of some bone regeneration adjuvants can be useful to enhance bone regeneration based on alloplastic materials, as is the case with PRF, a second-ge-neration blood by-product obtained through a specific protocol for centrifugation of the subject’s own blood. The aim of this review is to perform a systemic analysis of the histological and ultrastructural results for the use of synthetic bone grafts in combination with PRF and to analyze the resulting bone regeneration. Material and Method: A systematic search of the scientific literature was carried out between December 2002 and July 2017, in the MEDLINE, EMBASE, LILACS and SciELO databases. Results: The quality of the regenerated bone was superior when combined with the corresponding alloplastic material with PRF. Conclusion: The use of synthetic biomaterials together with PRF presents positive results in the stimulation of bone neoformation. However, the results are not totally conclusive due to the limited number of studies and the varied methodology used in different animal models.
Original languageAmerican English
Pages (from-to)79-86
Number of pages8
JournalAvances en Odontoestomatologia
Issue number2
StatePublished - 1 Mar 2018


  • Bone regeneration
  • PRF
  • Synthetic graft

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