Use of Human Umbilical Cord and Its Byproducts in Tissue Regeneration

Francesca Velarde, Verónica Castañeda, Emilia Morales, Mayra Ortega, Edwin Ocaña, Jose Álvarez-Barreto, Michelle Grunauer, Luis Eguiguren*, Andrés Caicedo

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations


    The fresh or cryopreserved human umbilical cord (HUC) and its byproducts, such as cells and extracts, have different uses in tissue regeneration. Defining what HUC byproduct is more effective in a particular application is a challenge. Furthermore, the methods of isolation, culture and preservation, may affect cell viability and regenerative properties. In this article, we review the HUC and its byproducts’ applications in research and clinical practice. We present our results of successful use of HUC as a patch to treat gastroschisis and its potential to be applied in other conditions. Our in vitro results show an increase in proliferation and migration of human fibroblasts by using an acellular HUC extract. Our goal is to promote standardization of procedures and point out that applications of HUC and its byproducts, as well as the resulting advances in regenerative medicine, will depend on rigorous quality control and on more research in this area.

    Original languageEnglish
    Article number117
    JournalFrontiers in Bioengineering and Biotechnology
    StatePublished - 10 Mar 2020

    Bibliographical note

    Funding Information:
    We are grateful to the health professionals of Hospital Carlos Andrade Mar?n and to Drs. A. Zurita and S. Nicola for the care provided to the patients. AC would like to thank Sistemas Medicos-USFQ (SIME-USFQ) for their support. Funding. This research was funded by the USFQ School of Medicine Grant (institutional code: HUBi 5502). The USFQ evaluated this project before its submission to Frontiers through grant proposals and bioethics review processes according to institutional criteria. Funding bodies did not play any role in the design, data collection, analysis, and interpretations of data or in writing the manuscript.

    Publisher Copyright:
    © Copyright © 2020 Velarde, Castañeda, Morales, Ortega, Ocaña, Álvarez-Barreto, Grunauer, Eguiguren and Caicedo.


    • cryopreserved allograft
    • gastroschisis
    • mesenchymal stem cells
    • regenerative medicine
    • tissue regeneration
    • umbilical cord
    • umbilical cord extracts
    • umbilical cord stem cells


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