Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches

Valentina Burckhardt-Bravo; Rodrigo Funes-Ferrada; Fernando Valenzuela

doi:10.1016/j.abd.2025.501249

Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches

Valentina Burckhardt-Bravo^*
, Rodrigo Funes-Ferrada
, Fernando Valenzuela

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Acne vulgaris is a chronic inflammatory condition with multifactorial pathogenesis. Despite the availability of numerous treatment options, there remains a need for safe, well-tolerated, and microbiome-preserving therapies. This narrative review explores recent advances in non-pharmacological acne treatments, focusing on various microbiome modulation strategies. It highlights emerging therapeutic modalities and their potential impact on clinical practice. Key findings from recent studies are summarized, providing insights for future research and practical applications in dermatology.

Original language	English
Article number	501249
Journal	Anais Brasileiros de Dermatologia
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.abd.2025.501249
State	Published - 1 Jan 2026

Bibliographical note

Publisher Copyright:
© 2025 Sociedade Brasileira de Dermatologia

Keywords

Acne vulgaris
Photochemotherapy
Skin microbiome
Therapeutics

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10.1016/j.abd.2025.501249

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title = "Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches",

abstract = "Acne vulgaris is a chronic inflammatory condition with multifactorial pathogenesis. Despite the availability of numerous treatment options, there remains a need for safe, well-tolerated, and microbiome-preserving therapies. This narrative review explores recent advances in non-pharmacological acne treatments, focusing on various microbiome modulation strategies. It highlights emerging therapeutic modalities and their potential impact on clinical practice. Key findings from recent studies are summarized, providing insights for future research and practical applications in dermatology.",

keywords = "Acne vulgaris, Photochemotherapy, Skin microbiome, Therapeutics",

author = "Valentina Burckhardt-Bravo and Rodrigo Funes-Ferrada and Fernando Valenzuela",

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year = "2026",

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AU - Burckhardt-Bravo, Valentina

AU - Funes-Ferrada, Rodrigo

AU - Valenzuela, Fernando

PY - 2026/1/1

Y1 - 2026/1/1

N2 - Acne vulgaris is a chronic inflammatory condition with multifactorial pathogenesis. Despite the availability of numerous treatment options, there remains a need for safe, well-tolerated, and microbiome-preserving therapies. This narrative review explores recent advances in non-pharmacological acne treatments, focusing on various microbiome modulation strategies. It highlights emerging therapeutic modalities and their potential impact on clinical practice. Key findings from recent studies are summarized, providing insights for future research and practical applications in dermatology.

AB - Acne vulgaris is a chronic inflammatory condition with multifactorial pathogenesis. Despite the availability of numerous treatment options, there remains a need for safe, well-tolerated, and microbiome-preserving therapies. This narrative review explores recent advances in non-pharmacological acne treatments, focusing on various microbiome modulation strategies. It highlights emerging therapeutic modalities and their potential impact on clinical practice. Key findings from recent studies are summarized, providing insights for future research and practical applications in dermatology.

KW - Acne vulgaris

KW - Photochemotherapy

KW - Skin microbiome

KW - Therapeutics

UR - https://www.scopus.com/pages/publications/105027536195

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DO - 10.1016/j.abd.2025.501249

M3 - Review article

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JO - Anais Brasileiros de Dermatologia

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IS - 1

M1 - 501249

ER -

Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches

Abstract

Bibliographical note

Keywords

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