Update on celiac disease

Felipe Moscoso J.*, Rodrigo Quera P.

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The prevalence of Celiac disease in the general population is approximately 1% and remains undiagnosed in a significant proportion of individuals. Its clinical presentation includes the classical malabsorption syndrome, unspecific and extra-intestinal manifestations, and silent celiac disease. The serologic diagnosis has an elevated sensitivity and specificity and, at least in adult population, it must be confirmed by biopsy in every case. Diagnosis in subjects already on gluten free diet includes HLA typing and gluten challenge with posterior serologic and histologic evaluation. The core of the treatment is the gluten free diet, which must be supervised by an expert nutritionist. Monitoring must be performed with serology beginning at 3-6 months, and with histology two years after the diagnosis, unless the clinical response is poor. Poor disease control is associated with complications such as lymphoma and small bowel adenocarcinoma. In the future, it is likely that new pharmacologic therapies will be available for the management of celiac disease.

Translated title of the contributionUpdate on celiac disease
Original languageSpanish
Pages (from-to)211-221
Number of pages11
JournalRevista Medica de Chile
Volume144
Issue number2
DOIs
StatePublished - Feb 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016, Sociedad Medica de Santiago. All rights reserved.

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