Type I diabetes mellitus in Chilean children under 5 years-old: Onset characteristics in contrast with other age groups

Francisca Eyzaguirre Croxatto, José Miguel Peláez D., Carolina Sepúlveda R., Ximena Gaete V., Ethel Codner D., Nancy Unanue M., Alejandra Ávila A., Francisca Ugarte P., Ricardo Silva A., Hernán García B.

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4 Scopus citations

Abstract

Background: During the last years, an increase in the incidence of DM1 in infants has been observed. Objective: to study the number of children younger than 5 years-old diagnosed with DM1 and compare clinical and laboratory features with older children at DM1 onset. Method: Study of the clinical and laboratory characteristics in subjects diagnosed with DM1 from 1998 to 2003 in Santiago. Patients were classified according to age in 3 groups: 0-4 (GI), 5-9 (GII) and 10-14 years-old (GIII). Results: 19,7% cases were younger than 5 years-old (GI n = 27), GII (43,8% n = 60) and GIII (36,5% n = 50). A shorter duration of symptoms was observed in GI (18,4 ± 23,7 vs 26,4 ± 27,4) (p < 0,0001) and HbA1c levels were lower in GII (10,1 ± 1,7 vs 11,8 ± 3,4%) (p < 0,0001) and in GIII (12,4 ± 2,6%) (p = 0,028). Glucose levels were similar among groups (p>0,05) and metabolic acidosis was more severe in GI (pH 7,14 ± 0,1 vs 7,19 ± 0,2 in GII and 7,26 ± 0,1 in GIII) (p < 0,0001). A concomitant infectious disease was observed in GI (33%), GII (20%) and GIII (28%) (p > 0,05). Conclusions: An important percentage of DM1 in children presents in subjects younger than 5 years-old. This group showed acute and severe clinical presentation with longer duration of symptoms, severe acidosis and lower HbA1c levels. It is necessary to evaluate carefully in order to suspect the diagnosis in this group.

Translated title of the contributionType I diabetes mellitus in Chilean children under 5 years-old: Onset characteristics in contrast with other age groups
Original languageSpanish
Pages (from-to)375-381
Number of pages7
JournalRevista Chilena de Pediatria
Volume77
Issue number4
StatePublished - Aug 2006
Externally publishedYes

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