Triggering and resolution of inflammation in NASH

Susanne Schuster, Daniel Cabrera, Marco Arrese, Ariel E. Feldstein*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

556 Scopus citations

Abstract

Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis. A central issue in this field relates to the identification of those factors that trigger inflammation, thus fuelling the transition from nonalcoholic fatty liver to NASH. These triggers of liver inflammation might have their origins outside the liver (such as in adipose tissue or the gut) as well as inside the organ (for instance, lipotoxicity, innate immune responses, cell death pathways, mitochondrial dysfunction and endoplasmic reticulum stress), both of which contribute to NASH development. In this Review, we summarize the currently available information on the key upstream triggers of inflammation in NASH. We further delineate the mechanisms by which liver inflammation is resolved and the implications of a defective pro-resolution process. A better knowledge of these mechanisms should help to design targeted therapies able to halt or reverse disease progression.

Original languageEnglish
Pages (from-to)349-364
Number of pages16
JournalNature Reviews Gastroenterology and Hepatology
Volume15
Issue number6
DOIs
StatePublished - 1 Jun 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Macmillan Publishers Ltd., part of Springer Nature.

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