TY - JOUR
T1 - Trasplante simultáneo de páncreas y riñón en diabetes mellitus tipo 1
T2 - Experiencia de un centro en Chile
AU - Alba, Andrea
AU - Morales, Jorge
AU - Ferrario, Mario
AU - Zehnder, Carlos
AU - Aguiló, Jorge
AU - Zavala, Carlos
AU - Herzog, Cristina
AU - Calabran, Lorena
AU - Contreras, Luis
AU - Espinoza, Ricardo
AU - Buckel, Erwin
AU - Fierro, Juan Alberto
PY - 2011/1
Y1 - 2011/1
N2 - Background: Simultaneous kidney and pancreas transplantation (SKPT) is the best alternative for end stage renal disease among patients with insulin dependent diabetes mellitus. Aim: To report our experience with SKPT. Material and Methods: Retrospective analysis of 12 recipients of SKPT transplanted in one center starting in 1994, with a mean follow-up period of 6.8 years (2-15). Results: Eleven of 12 recipients were in chronic hemodialysis before SKPT. Mean A, B, DR and HLA mismatch was 4.3. Mean preformed anti HLA antibodies was 3.3 %. Mean cold ischemia times for pancreas and kidney were 6 and 10 hours, respectively. In the fi rst eight cases, the pancreas was drained to the bladder, and in the last four, an enteric drainage was performed. Eleven recipients were induced with antibodies, and maintenance immunosuppression consisted of Cyclosporine or Tacrolimus plus an antiproliferative agent. Ten year patient survival was 70 %. Pancreas and kidney survival, defi ned by insulin and dialysis independence, were 72 and 73% respectively. Fifty percent of recipients experienced acute graft rejection (cellular or humoral), with good response to treatment except in one case. Conclusions: This experience shows that SKPT is associated with an excellent patient survival associated to insulin and dialysis independence in 70% of patients at 10 years.
AB - Background: Simultaneous kidney and pancreas transplantation (SKPT) is the best alternative for end stage renal disease among patients with insulin dependent diabetes mellitus. Aim: To report our experience with SKPT. Material and Methods: Retrospective analysis of 12 recipients of SKPT transplanted in one center starting in 1994, with a mean follow-up period of 6.8 years (2-15). Results: Eleven of 12 recipients were in chronic hemodialysis before SKPT. Mean A, B, DR and HLA mismatch was 4.3. Mean preformed anti HLA antibodies was 3.3 %. Mean cold ischemia times for pancreas and kidney were 6 and 10 hours, respectively. In the fi rst eight cases, the pancreas was drained to the bladder, and in the last four, an enteric drainage was performed. Eleven recipients were induced with antibodies, and maintenance immunosuppression consisted of Cyclosporine or Tacrolimus plus an antiproliferative agent. Ten year patient survival was 70 %. Pancreas and kidney survival, defi ned by insulin and dialysis independence, were 72 and 73% respectively. Fifty percent of recipients experienced acute graft rejection (cellular or humoral), with good response to treatment except in one case. Conclusions: This experience shows that SKPT is associated with an excellent patient survival associated to insulin and dialysis independence in 70% of patients at 10 years.
KW - Kidney transplantation
KW - Organ transplantation
KW - Pancreas transplantation
UR - http://www.scopus.com/inward/record.url?scp=79955630753&partnerID=8YFLogxK
U2 - 10.4067/S0034-98872011000100002
DO - 10.4067/S0034-98872011000100002
M3 - Article
C2 - 21526312
AN - SCOPUS:79955630753
SN - 0034-9887
VL - 139
SP - 11
EP - 18
JO - Revista Medica de Chile
JF - Revista Medica de Chile
IS - 1
ER -