Transplantation of fecal matter in octogenarian patients with recurrent clostridioides difficile infection

Rodrigo Quera*, Rocío Sedano, Ricardo Espinoza, Daniela Rivera

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Clostridioides (formerly Clostridium) difficile infection has become a major health problem due to the increase in its incidence, severity, and recurrence. In this last scenario, age over 65 has been associated with a more unfavorable evolution. Risk factors such as the presence of altered immunity, comorbidities, malnutrition, polypharmacy, and changes in the intestinal microbiota would explain this higher risk in this group of patients. On the other hand, fecal microbiota transplantation (FMT) is an effective strategy in the treatment of recurrent Clostridioides difficile infection when standard therapy fails. Recently published guidelines suggest that this strategy can be used from the second recurrence. However, few studies have evaluated the results of the FMT in patients over 65 years old, and for our knowledge, there is limited national experience in this group of patients. We present two cases of TMF in octogenarian patients with a recurrent infection due to Clostridioides difficile, with satisfactory recovery at the long term.

Translated title of the contributionTransplantation of fecal matter in octogenarian patients with recurrent clostridioides difficile infection
Original languageSpanish
Pages (from-to)536-540
Number of pages5
JournalRevista Chilena de Infectologia
Volume36
Issue number4
DOIs
StatePublished - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019, Sociedad Chilena de Infectologia. All rights reserved.

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