Transforming growth factor beta type I role in neurodegeneration: Implications for Alzheimer’s disease

Lisbell D. Estrada*, Luciana Oliveira-Cruz, Daniel Cabrera

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Alzheimer's disease is a neurodegenerative condition affecting millions of people worldwide. Alzheimer's symptoms include memory loss and cognitive decline. Pathologically, the hallmarks of Alzheimer´s are the presence of Amyloid beta-plaques, neurofibrillary tangles, and neuronal loss. Unfortunately, no cure is presently available and current treatments are only symptomatic. Transforming growth factor beta type I (TGF-β1) is a trophic factor involved in neuronal development and synaptic plasticity. Impairment of TGF-β1 signaling is associated with exacerbated Aβ deposition and neurofibrillary tangle formation, which increases neurodegeneration. Aging and chronic inflammation reduce the canonical TGF-β1/Smad signaling, facilitating cytotoxic activation of microglia and microglia-mediated neurodegeneration This review gathers together evidence for a neuroprotective role of TGF-β in Alzheimer’s disease. Restoring TGF-β1 signaling impairment may be a new pharmacological strategy Alzheimer’s treatment.

Original languageEnglish
Pages (from-to)1180-1188
Number of pages9
JournalCurrent Protein and Peptide Science
Volume19
Issue number12
DOIs
StatePublished - 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Bentham Science Publishers.

Keywords

  • Alzheimer´s disease
  • Amyloid-beta
  • Microglia
  • Neuroinflammation
  • Neuroprotection
  • Oligomers
  • Smad signaling
  • Transforming growth factor-β1

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