The round window membrane following application of staphylococcal exotoxin: An electron microscopic study

Patricia A. Schachern, Michael M. Paparella, Marcos Goycoolea, Burt Goldberg, Patrick Schlievert*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The round window membrane has been considered as a pathway for the passage of toxic substances from the middle ear cavity to the vestibular labyrinth in cases of otitis media. To determine the role of the round window membrane in this passage, chinchillas were given intrabullar inoculations with staphylococcal exotoxin and the round window membranes were examined electron microscopically. We observed cytoplasmic vacuolization, intercellular edema, cellular and nuclear swelling of the surface epithelia and polymorphonuclear leukocyte (PMN) infiltration of the fibrous layer. Light microscopic observation of the labyrinth revealed PMN infiltration of the most basal portion of the scala tympani. These findings demonstrate a chemotactic effect of the toxin for PMNs and support the ccr.;ept of the round window membrane as an important avenue of entry.

Original languageEnglish
Pages (from-to)2007-2017
Number of pages11
JournalLaryngoscope
Volume91
Issue number12
StatePublished - Dec 1981
Externally publishedYes

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