The role of long non-coding rnas in trophoblast regulation in preeclampsia and intrauterine growth restriction

Lara Monteiro, Reyna Peñailillo, Mario Sánchez, Stephanie Acuña-Gallardo, Max Mönckeberg, Judith Ong, Mahesh Choolani, Sebastián Illanes, Gino Nardocci

Research output: Contribution to journalArticlepeer-review

Abstract

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

Original languageEnglish
Article number970
JournalGenes
Volume12
Issue number7
DOIs
StatePublished - Jun 2021

Bibliographical note

Funding Information:
This research was funded by ANID/CONICYT?FONDECYT de Iniciaci?n 11190998 (to G.N.); ANID/CONICYT?FONDECYT de Iniciaci?n 11181249 (to L.J.M.); ANID/CONICYT? FONDECYT Regular 1201851 (to S.E.I.); ANID/CONICYT?FONDECYT Postdoctorado 3160622 (to M.S.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Intrauterine growth restriction
  • Long non-coding RNAs
  • Preeclampsia

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