The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction

Lara Monteiro; Reyna Peñailillo; Mario Sánchez; Stephanie Acuña-Gallardo; Max Mönckeberg; Judith Ong; Mahesh Choolani; Sebastián Illanes; Gino Nardocci

doi:10.3390/genes12070970

The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction

Lara Monteiro, Reyna Peñailillo, Mario Sánchez, Stephanie Acuña-Gallardo, Max Mönckeberg, Judith Ong, Mahesh Choolani, Sebastián Illanes, Gino Nardocci^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

Original language	English
Article number	970
Journal	Genes
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/genes12070970
State	Published - 1 Jun 2021

Bibliographical note

Funding Information:
This research was funded by ANID/CONICYT?FONDECYT de Iniciaci?n 11190998 (to G.N.); ANID/CONICYT?FONDECYT de Iniciaci?n 11181249 (to L.J.M.); ANID/CONICYT? FONDECYT Regular 1201851 (to S.E.I.); ANID/CONICYT?FONDECYT Postdoctorado 3160622 (to M.S.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Intrauterine growth restriction
Long non-coding RNAs
Preeclampsia

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abstract = "Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.",

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note = "Funding Information: This research was funded by ANID/CONICYT?FONDECYT de Iniciaci?n 11190998 (to G.N.); ANID/CONICYT?FONDECYT de Iniciaci?n 11181249 (to L.J.M.); ANID/CONICYT? FONDECYT Regular 1201851 (to S.E.I.); ANID/CONICYT?FONDECYT Postdoctorado 3160622 (to M.S.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Acuña-Gallardo, Stephanie

AU - Mönckeberg, Max

AU - Ong, Judith

AU - Choolani, Mahesh

AU - Illanes, Sebastián

AU - Nardocci, Gino

N1 - Funding Information: This research was funded by ANID/CONICYT?FONDECYT de Iniciaci?n 11190998 (to G.N.); ANID/CONICYT?FONDECYT de Iniciaci?n 11181249 (to L.J.M.); ANID/CONICYT? FONDECYT Regular 1201851 (to S.E.I.); ANID/CONICYT?FONDECYT Postdoctorado 3160622 (to M.S.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

AB - Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

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The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction

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