The Permeability of the Round Window Membrane During Otitis Media

Patricia A. Schachern*, Michael M. Paparella, Marcos V. Goycoolea, Arndt J. Duvall, Young Bin Choo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Studies of the permeability of the round window membrane (RWM) during otitis media are important because toxins and cellular components that occur in otitis media as well as pharmacologic agents used in treating the disease have the potential to cross the RWM and pass into the inner ear. Twenty-five cats were evaluated electron microscopically as to the passage of a tracer, horseradish peroxidase, through normal RWMs and RWMs three days, one week, and two weeks following eustachian tube obstruction. Passage at three days following obstruction was similar to passage through the normal RWM. Following one to two weeks of obstruction, the permeability of the membrane was drastically reduced. The reduction in permeability was probably due to (1) the presence of residual effusion overlying the membrane, (2) the presence of granulation tissue within the niche, and (3) a thickening of the RWM. (Arch Otolaryngol Head Neck Surg 1987;113:625-629)

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume113
Issue number6
DOIs
StatePublished - Jun 1987
Externally publishedYes

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