TY - JOUR
T1 - The oral-gut-circulatory axis
T2 - from homeostasis to colon cancer
AU - Tortora, Sofia C.
AU - Agurto, Maria Gonzalez
AU - Martello, Laura A.
N1 - © 2023 Tortora, Agurto and Martello.
PY - 2023/11/7
Y1 - 2023/11/7
N2 - The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer.
AB - The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer.
KW - circulation
KW - colon cancer
KW - dysbiosis
KW - immune response
KW - microbiota
KW - oral-gut axis
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85177569473&origin=resultslist&sort=plf-f&src=s&sid=fc604441002ddebc637e9d1ff193d281&sot=b&sdt=b&s=TITLE-ABS-KEY%28The+oral-gut-circulatory+axis%3A+from+homeostasis+to+colon+cancer%29&sl=96&sessionSearchId=fc604441002ddebc637e9d1ff193d281&relpos=0
U2 - 10.3389/fcimb.2023.1289452
DO - 10.3389/fcimb.2023.1289452
M3 - Article
SN - 2235-2988
VL - 13
SP - 1
EP - 15
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 1289452
ER -
