The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Noymar Luque-Campos; Felipe A. Bustamante-Barrientos; Carolina Pradenas; Cynthia García; María Jesús Araya; Candice Bohaud; Rafael Contreras-López; Roberto Elizondo-Vega; Farida Djouad; Patricia Alejandra Luz Crawford; Ana María Vega-Letter

doi:10.3389/fimmu.2021.624746

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Noymar Luque-Campos
, Felipe A. Bustamante-Barrientos
, Carolina Pradenas
, Cynthia García
, María Jesús Araya
, Candice Bohaud
, Rafael Contreras-López
, Roberto Elizondo-Vega
, Farida Djouad
, Patricia Alejandra Luz Crawford^*
, Ana María Vega-Letter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Original language	English
Article number	624746
Pages (from-to)	624746
Journal	Frontiers in Immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.624746
State	Published - 4 Jun 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Luque-Campos, Bustamante-Barrientos, Pradenas, García, Araya, Bohaud, Contreras-López, Elizondo-Vega, Djouad, Luz-Crawford and Vega-Letter.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Cell Communication
Cell Plasticity
Cellular Microenvironment
Cellular Reprogramming
Energy Metabolism
Humans
Inflammation Mediators/metabolism
Macrophages/immunology
Mesenchymal Stem Cells/immunology
Phenotype
Signal Transduction

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10.3389/fimmu.2021.624746

Cite this

Luque-Campos, N., Bustamante-Barrientos, F. A., Pradenas, C., García, C., Araya, M. J., Bohaud, C., Contreras-López, R., Elizondo-Vega, R., Djouad, F., Luz Crawford, P. A., & Vega-Letter, A. M. (2021). The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming. Frontiers in Immunology, 12, 624746. Article 624746. https://doi.org/10.3389/fimmu.2021.624746

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abstract = "Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage{\textquoteright}s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC{\textquoteright}s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.",

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note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Luque-Campos, Bustamante-Barrientos, Pradenas, Garc{\'i}a, Araya, Bohaud, Contreras-L{\'o}pez, Elizondo-Vega, Djouad, Luz-Crawford and Vega-Letter.",

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Luque-Campos, N, Bustamante-Barrientos, FA, Pradenas, C, García, C, Araya, MJ, Bohaud, C, Contreras-López, R, Elizondo-Vega, R, Djouad, F, Luz Crawford, PA & Vega-Letter, AM 2021, 'The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming', Frontiers in Immunology, vol. 12, 624746, pp. 624746. https://doi.org/10.3389/fimmu.2021.624746

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T1 - The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

AU - Luque-Campos, Noymar

AU - Bustamante-Barrientos, Felipe A.

AU - Pradenas, Carolina

AU - García, Cynthia

AU - Araya, María Jesús

AU - Bohaud, Candice

AU - Contreras-López, Rafael

AU - Elizondo-Vega, Roberto

AU - Djouad, Farida

AU - Luz Crawford, Patricia Alejandra

AU - Vega-Letter, Ana María

PY - 2021/6/4

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AB - Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

KW - Animals

KW - Cell Communication

KW - Cell Plasticity

KW - Cellular Microenvironment

KW - Cellular Reprogramming

KW - Energy Metabolism

KW - Humans

KW - Inflammation Mediators/metabolism

KW - Macrophages/immunology

KW - Mesenchymal Stem Cells/immunology

KW - Phenotype

KW - Signal Transduction

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SN - 1664-3224

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SP - 624746

JO - Frontiers in Immunology

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The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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