The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Noymar Luque-Campos, Felipe A. Bustamante-Barrientos, Carolina Pradenas, Cynthia García, María Jesús Araya, Candice Bohaud, Rafael Contreras-López, Roberto Elizondo-Vega, Farida Djouad, Patricia Alejandra Luz Crawford*, Ana María Vega-Letter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Original languageEnglish
Article number624746
Pages (from-to)624746
JournalFrontiers in Immunology
StatePublished - 4 Jun 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Luque-Campos, Bustamante-Barrientos, Pradenas, García, Araya, Bohaud, Contreras-López, Elizondo-Vega, Djouad, Luz-Crawford and Vega-Letter.


  • Animals
  • Cell Communication
  • Cell Plasticity
  • Cellular Microenvironment
  • Cellular Reprogramming
  • Energy Metabolism
  • Humans
  • Inflammation Mediators/metabolism
  • Macrophages/immunology
  • Mesenchymal Stem Cells/immunology
  • Phenotype
  • Signal Transduction


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