The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse

Rudolf C. Kuppers; Leonardo D. Epstein; Ingrid M. Outschoorn; Noel R. Rose

doi:10.1007/BF00176157

The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse

Rudolf C. Kuppers^*, Leonardo D. Epstein, Ingrid M. Outschoorn, Noel R. Rose

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Igh^b allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Igh^b congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Igh^b mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F₁ mouse also produced reduced IgG2a of the Igh^b (B6) allotype but not Igh^j (CBA) allotype.

Original language	English
Pages (from-to)	404-411
Number of pages	8
Journal	Immunogenetics
Volume	39
Issue number	6
DOIs	https://doi.org/10.1007/BF00176157
State	Published - Apr 1994
Externally published	Yes

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title = "The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse",

abstract = "The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not Ighj (CBA) allotype.",

author = "Kuppers, {Rudolf C.} and Epstein, {Leonardo D.} and Outschoorn, {Ingrid M.} and Rose, {Noel R.}",

year = "1994",

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AU - Epstein, Leonardo D.

AU - Outschoorn, Ingrid M.

AU - Rose, Noel R.

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AB - The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not Ighj (CBA) allotype.

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The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse

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