The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse

Rudolf C. Kuppers, Leonardo David Epstein, Ingrid M. Outschoorn, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

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Abstract

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not Ighj (CBA) allotype.

Original languageEnglish
Pages (from-to)404-411
Number of pages8
JournalImmunogenetics
Volume39
Issue number6
DOIs
StatePublished - Apr 1994
Externally publishedYes

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