The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

Azita Tehranchi, Hossein Behnia, Fereydoun Pourdanesh, Parsa Behnia*, Nelson Pinto, Farnaz Younessian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objective: The aim of this study was to evaluate the effect of LPRF, placed in extraction sockets, on orthodontic tooth movement (OTM). Materials and Methods: Thirty extraction sockets from eight patients (five males, three females, with a mean age of 17.37 years; range 12-25 years) requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. In one randomly selected quadrant of each jaw, the extraction socket was preserved as the experimental group by immediate placement of LPRF in the extraction socket. The other quadrant served as the control group for secondary healing. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. A piece of 0.016 × 0.022-inch stainless steel wire was used as the main arch wire. The amount of OTM was measured on the study casts at eight time points with 2-week intervals for 3 months. Analysis of random effect model was performed for the purpose of comparison between the experimental and control groups. Results: According to the random effect model, a statistically significant difference was found between the experimental and control group in rate of OTM (P = 0.006). Conclusion: According to the results, application of LPRF, as an interdisciplinary approach combining orthodontics and surgery, may accelerate OTM, particularly in extraction cases.

Original languageEnglish
Pages (from-to)350-357
Number of pages8
JournalEuropean Journal of Dentistry
Issue number3
StatePublished - 1 Jul 2018

Bibliographical note

Funding Information:
This study was extracted from a undergraduate thesis of Parsa Behnia under supervision of Dr. Fereydoun Pourdanesh at Shahid Beheshti School of Dentistry. The authors wish to thank the Dental Research Center, Shahid Beheshti University of Medical Sciences, for support of this project.

Publisher Copyright:
© 2018 European Journal of Dentistry | Published by Wolters Kluwer - Medknow.


  • Leukocyte platelet rich fibrin
  • orthodontic tooth movement
  • plasma
  • platelet concentrate
  • platelet-rich fibrin
  • platelet-rich plasma


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