The current situation of meningococcal disease in Latin America and updated Global Meningococcal Initiative (GMI) recommendations

On behalf of the Global Meningococcal Initiative

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The Global Meningococcal Initiative (GMI) was established in 2009 and comprises an international team of scientists, clinicians, and public health officials with expertise in meningococcal disease (MD). Its primary goal is to promote global prevention of MD through education, research, international cooperation, and developing recommendations that include decreasing the burden of severe disease. The group held its first roundtable meeting with experts from Latin American countries in 2011, and subsequently proposed several recommendations to reduce the regional burden of MD. A second roundtable meeting was convened with Latin American representatives in June 2013 to reassess MD epidemiology, vaccination strategies, and unmet needs in the region, as well as to update the earlier recommendations. Special emphasis was placed on the emergence and spread of serogroup W disease in Argentina and Chile, and the control measures put in place in Chile were a particular focus of discussions. The impact of routine meningococcal vaccination programs, notably in Brazil, was also evaluated. There have been considerable improvements in MD surveillance systems and diagnostic techniques in some countries (e.g., Brazil and Chile), but the lack of adequate infrastructure, trained personnel, and equipment/reagents remains a major barrier to progress in resource-poor countries. The Pan American Health Organization's Revolving Fund is likely to play an important role in improving access to meningococcal vaccines in Latin America. Additional innovative approaches are needed to redress the imbalance in expertise and resources between countries, and thereby improve the control of MD. In Latin America, the GMI recommends establishment of a detailed and comprehensive national/regional surveillance system, standardization of laboratory procedures, adoption of a uniform MD case definition, maintaining laboratory-based surveillance, replacement of polysaccharide vaccines with conjugate formulations (wherever possible), monitoring and evaluating implemented vaccination strategies, conducting cost-effectiveness studies, and developing specific recommendations for vaccination of high-risk groups.

Original languageEnglish
Pages (from-to)6529-6536
Number of pages8
JournalVaccine
Volume33
Issue number48
DOIs
StatePublished - 27 Nov 2015

Bibliographical note

Funding Information:
The authors are all members of the Global Meningococcal Initiative (GMI). The GMI is funded by an educational grant from Sanofi Pasteur; however, the group is not led in any way by the company. GMI members determine meeting agenda items and lead the discussions and outputs. Sanofi Pasteur representatives may attend the meetings, but in the role of observers only, and they do not influence the findings of the group.

Funding Information:
MAPS has received grants to support research projects and speaker's honoraria from GlaxoSmithKline (GSK), Novartis, Sanofi Pasteur, and Pfizer. MO has received a grant from Novartis to study 4CMenB in adolescents. MTVB has no further conflicts or financial interests to declare. MCCB has received lecture fees from Pfizer and GSK. MCOG has received consultancy fees from Novartis. APSL has received lecture fees from Novartis and Sanofi Pasteur. GM has no further conflicts or financial interests to declare. JAV has received grants to support research projects and speaker's and/or consultant fees from GSK, Novartis, Sanofi Pasteur, Baxter BioSciences, and Pfizer. ELL has received honoraria to act as a speaker and/or consultant from Novartis, Pfizer, MSD, and Sanofi Pasteur. M-KT performs contract research and expertise on behalf of the Institut Pasteur for GSK, Novartis, Pfizer, and Sanofi Pasteur. RB performs contract research on behalf of Public Health England for Baxter Biosciences, GSK, Novartis, Pfizer, Sanofi Pasteur, and Sanofi Pasteur MSD.

Funding Information:
Medical writing support was provided by Shelley Lindley, PhD, of PAREXEL, which was funded by Sanofi Pasteur .

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

  • Epidemiology
  • Global Meningococcal Initiative
  • Meningococcal disease
  • Serogroup W
  • Surveillance
  • Vaccination

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