The axonal endoplasmic reticulum: One organelle—many functions in development, maintenance, and plasticity

Alejandro Luarte, Víctor Hugo Cornejo, Francisca Bertin, Javiera Gallardo, Andrés Couve*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the localization of the organelle in axons has been known for nearly half a century. However, the relevance of the axonal ER is only beginning to emerge. In this review, we discuss the structure of the ER in axons, examining the role of ER-shaping proteins and highlighting reticulons. We analyze the multiple functions of the ER and their potential contribution to axonal physiology. First, we examine the emerging roles of the axonal ER in lipid synthesis, protein translation, processing, quality control, and secretory trafficking of transmembrane proteins. We also review the impact of the ER on calcium dynamics, focusing on intracellular mechanisms and functions. We describe the interactions between the ER and endosomes, mitochondria, and synaptic vesicles. Finally, we analyze available proteomic data of axonal preparations to reveal the dynamic functionality of the ER in axons during development. We suggest that the dynamic proteome and a validated axonal interactome, together with state-of-the-art methodologies, may provide interesting research avenues in axon physiology that may extend to pathology and regeneration.

Original languageEnglish
Pages (from-to)181-208
Number of pages28
JournalDevelopmental Neurobiology
Volume78
Issue number3
DOIs
StatePublished - Mar 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

  • axon
  • Ca2
  • lipid metabolism
  • neurons
  • protein synthesis
  • proteome
  • trafficking
  • transmembrane proteins

Fingerprint

Dive into the research topics of 'The axonal endoplasmic reticulum: One organelle—many functions in development, maintenance, and plasticity'. Together they form a unique fingerprint.

Cite this